溶酶体
化学
血脑屏障
细胞外
嵌合体(遗传学)
细胞生物学
淀粉样蛋白(真菌学)
体外
生物化学
神经科学
生物
基因
酶
中枢神经系统
无机化学
作者
Qiang Cai,Quazi T.H. Shubhra
出处
期刊:Neuron
[Elsevier]
日期:2023-09-01
卷期号:111 (18): 2778-2780
被引量:2
标识
DOI:10.1016/j.neuron.2023.08.028
摘要
In a recent Chem article, Liu et al. 1 Liu Z. Deng Q. Qin G. Yang J. Zhang H. Ren J. Qu X. Biomarker-activated multifunctional lysosome-targeting chimeras mediated selective degradation of extracellular amyloid fibrils. Chem. 2023; 9: 2016-2038https://doi.org/10.1016/j.chempr.2023.06.003 Abstract Full Text Full Text PDF Scopus (1) Google Scholar introduced polydopamine-based lysosome-targeting chimeras (KPLYs). In in vitro cellular models, KPLYs adeptly cross the blood-brain barrier to target and eliminate β-amyloid aggregates. They also reduce inflammation and modulate microglial activity. In a recent Chem article, Liu et al. 1 Liu Z. Deng Q. Qin G. Yang J. Zhang H. Ren J. Qu X. Biomarker-activated multifunctional lysosome-targeting chimeras mediated selective degradation of extracellular amyloid fibrils. Chem. 2023; 9: 2016-2038https://doi.org/10.1016/j.chempr.2023.06.003 Abstract Full Text Full Text PDF Scopus (1) Google Scholar introduced polydopamine-based lysosome-targeting chimeras (KPLYs). In in vitro cellular models, KPLYs adeptly cross the blood-brain barrier to target and eliminate β-amyloid aggregates. They also reduce inflammation and modulate microglial activity. Biomarker-activated multifunctional lysosome-targeting chimeras mediated selective degradation of extracellular amyloid fibrilsLiu et al.ChemJuly 3, 2023In BriefWe design, synthesize, and select Pittsburgh compound B (PiB)-derived suitable chimera molecules and then construct multifunctional polydopamine-based LYTACs (KPLYs) with blood-brain barrier permeability and activatable Aβ degradation ability used for Alzheimer’s disease treatment. Full-Text PDF
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