Overcoming blood-brain barrier for targeted delivery of lysosome-targeting chimeras

In a recent Chem article, Liu et al.1 introduced polydopamine-based lysosome-targeting chimeras (KPLYs). In in vitro cellular models, KPLYs adeptly cross the blood-brain barrier to target and eliminate β-amyloid aggregates. They also reduce inflammation and modulate microglial activity.