化学
合成子
废止
催化作用
氧化磷酸化
功能群
有机化学
药物化学
组合化学
生物化学
聚合物
作者
Kai Guo,Qinghuan Wu,Gaochen Xu,Yuguang Li,Lei Shen,Zhenggang Fang,Jindian Duan
标识
DOI:10.1002/adsc.202301069
摘要
Abstract A Cu(I)‐catalyzed [4+2] oxidative annulation of α , β ‐unsaturated ketoxime acetates with cyclopropanols has been developed for the synthesis of 2,4,5‐trisubstituted pyridines in 28–76% yields. This method employs cyclopropanols as C2 synthons and features various functional group compatibility and gram‐scale synthesis. In addition, a plausible reaction pathway was proposed based on the mechanism studies.
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