Plastoquinone synthesis inhibition by tetrabromo biphenyldiol as a widespread algicidal mechanism of marine bacteria

生物 机制(生物学) 细菌 微生物学 塑料醌 基因 植物 生态学 生物化学 遗传学 叶绿体 认识论 类囊体 哲学
作者
Zenghu Zhang,Dehai Li,Ruize Xie,Ruoyu Guo,Shailesh Nair,Huan Han,Guojian Zhang,Qun Zhao,Lihua Zhang,Nianzhi Jiao,Yongyu Zhang
出处
期刊:The ISME Journal [Springer Nature]
卷期号:17 (11): 1979-1992 被引量:13
标识
DOI:10.1038/s41396-023-01510-0
摘要

Abstract Algae and bacteria have complex and intimate interactions in the ocean. Besides mutualism, bacteria have evolved a variety of molecular-based anti-algal strategies. However, limited by the unknown mechanism of synthesis and action of these molecules, these strategies and their global prevalence remain unknown. Here we identify a novel strategy through which a marine representative of the Gammaproteobacteria produced 3,3’,5,5’-tetrabromo-2,2’-biphenyldiol (4-BP), that kills or inhibits diverse phytoplankton by inhibiting plastoquinone synthesis and its effect cascades to many other key metabolic processes of the algae. Through comparative genomic analysis between the 4-BP-producing bacterium and its algicidally inactive mutant, combined with gene function verification, we identified the gene cluster responsible for 4-BP synthesis, which contains genes encoding chorismate lyase, flavin-dependent halogenase and cytochrome P450. We demonstrated that in near in situ simulated algal blooming seawater, even low concentrations of 4-BP can cause changes in overall phytoplankton community structure with a decline in dinoflagellates and diatoms. Further analyses of the gene sequences from the Tara Oceans expeditions and 2750 whole genome sequences confirmed the ubiquitous presence of 4-BP synthetic genes in diverse bacterial members in the global ocean, suggesting that it is a bacterial tool potentially widely used in global oceans to mediate bacteria-algae antagonistic relationships.
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