How the circadian nuclear orphan receptor REV-ERBα represses transcription: Temporal and spatial phase separation combined

In this issue of Molecular Cell, Zhu et al. 1 Zhu K. Celwyn I.J. Guan D. Xiao Y. Wang Y. Wang X. Hu W. Jang C. Cheng L. Casellas R. Lazar M.A. An Intrinsic Disorder Region Controlling Condensation of a Circadian Clock Component and Rhythmic Transcription in the Liver. Mol Cell. 2023; 83https://doi.org/10.1016/j.molcel.2023.09.010 Abstract Full Text Full Text PDF Google Scholar demonstrate that REV-ERBα and its co-repressor NCOR1 are assembled into daytime-dependent liquid droplets that constitute hubs in which the transcription of multiple REV-ERBα target genes is simultaneously repressed. In this issue of Molecular Cell, Zhu et al. 1 Zhu K. Celwyn I.J. Guan D. Xiao Y. Wang Y. Wang X. Hu W. Jang C. Cheng L. Casellas R. Lazar M.A. An Intrinsic Disorder Region Controlling Condensation of a Circadian Clock Component and Rhythmic Transcription in the Liver. Mol Cell. 2023; 83https://doi.org/10.1016/j.molcel.2023.09.010 Abstract Full Text Full Text PDF Google Scholar demonstrate that REV-ERBα and its co-repressor NCOR1 are assembled into daytime-dependent liquid droplets that constitute hubs in which the transcription of multiple REV-ERBα target genes is simultaneously repressed.