磁共振成像
光动力疗法
材料科学
纳米颗粒
胶质瘤
PEG比率
纳米复合材料
核磁共振
纳米技术
生物医学工程
医学
癌症研究
化学
放射科
物理
财务
经济
有机化学
作者
Feng Xing,Jie Huang,Yi Zhao,Hang Qu,Yu Han,Wei Wang
标识
DOI:10.1166/jbn.2022.3351
摘要
One of the most common brain cancer type is gliomas. Although traditional multi-modal therapy has made some progress, overall poor prognosis and low long-run rate of patient’s survival still persist. Due to its selective, noninvasive and repetitive nature, photo-dynamic/photo-thermal therapy (PDT/PTT) is considered to enhance therapeutic effect of glioma. We report a new type of polydopamine (PDA) nanoparticle with targeting ability and excellent PDT/PTT synergistic effect. The Mn 2+ chelated nanocomposite material exhibited a favorable contrast T1-weighted magnetic resonance images (MRI). In the U251 tumor-bearing mouse model, near-infrared (NIR) imaging and MRI-guided PDT/PTT achieved significant synergistic therapeutic effects compared to their single treatment methods. Conclusively, PDA-PEG-Ce6-Mn nanoparticle demonstrated high potential in the diagnosis and treatment of glioma.
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