Enantioselective aza-Friedel-Crafts Alkylation of Aniline Derivatives with Cyclic N-Sulfonyl α-Ketiminoesters: The Effect of Catalyst Confinement and The Rationale Behind the High Enantioselectivity

Transition metal complex-catalyzed enantioselective aza-Friedel-Crafts alkylation of ketimines with aniline derivatives have been problematic due to the relatively low reactivity of these reactants. Herein, we will show that using structurally...