癌症研究
食管鳞状细胞癌
生物
钥匙(锁)
逃避(道德)
免疫系统
基底细胞
肿瘤科
癌
免疫学
医学
内科学
生态学
作者
Kyung-Pil Ko,Yuanjian Huang,Shengzhe Zhang,Gengyi Zou,Bong-Jun Kim,Jie Zhang,Sohee Jun,Cecilia Martin,Karen J. Dunbar,Gizem Efe,Anil K. Rustgi,Hiroshi Nakagawa,Jae‐Il Park
出处
期刊:Gastroenterology
[Elsevier BV]
日期:2023-05-29
卷期号:165 (3): 613-628.e20
被引量:65
标识
DOI:10.1053/j.gastro.2023.05.030
摘要
Our study unveils that loss of TP53, CDKN2A, and NOTCH1 induces esophageal neoplasia and immune evasion for ESCC initiation and proposes the CCL2 blockade as a viable option for targeting PCN-type ESCC.
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