电针
肠梗阻
医学
交感神经系统
交感神经切除术
免疫系统
刺激
肠神经系统
受体
胃肠功能
去甲肾上腺素
内科学
内分泌学
药理学
免疫学
针灸科
病理
多巴胺
替代医学
血压
作者
Yi-Duo Liu,Yue-Jie Li,Jin Huang,Jing‐Wen Yang,Cun-Zhi Liu,Guang‐Xia Shi,Nana Yang
出处
期刊:American Journal of Physiology-regulatory Integrative and Comparative Physiology
[American Physiological Society]
日期:2025-08-05
卷期号:329 (3): R495-R505
标识
DOI:10.1152/ajpregu.00034.2025
摘要
Postoperative ileus (POI) is a prevalent complication resulting from an imbalance in sympathetic activity or dysregulation of the intestinal immune system. Research has shown that interactions between the peripheral nervous system and immune system modulate intestinal functions. Electroacupuncture (EA) has been shown to ameliorate gastrointestinal dysmotility in patients with POI; however, the specific pathways and molecular mechanisms underlying its effects remain unclear. Here, we reported the signaling pathways that mediate the regulatory effects of EA in POI. Our findings indicated that EA ameliorated gastrointestinal dysmotility, inhibited celiac sympathetic overactivation, and reduced norepinephrine (NE) release. Notably, NE released by the sympathetic nerve terminals regulates the immune system primarily via its stimulation of α2-adrenoceptors (α2-ARs). α2-ARs could regulate macrophage activation in POI and were the key receptors for macrophages to perform neuroimmunomodulatory functions. Furthermore, sympathectomy and α2-ARs antagonist could mimic the improvement effects of EA on gastrointestinal motility and inflammatory response. Our findings demonstrated the pivotal function of the NE-α2-ARs signaling pathways in the modulation of POI, potentially contributing to the development of EA-based therapeutic interventions for gastrointestinal dysmotility disorders after surgery.NEW & NOTEWORTHY Electroacupuncture (EA) ameliorated gastrointestinal dysmotility and inhibited celiac sympathetic overactivation. The α2-adrenergic signaling pathway was involved in the regulation of gastrointestinal dysmotility and was regulated by EA stimulation. The α2-adrenoceptors (α2-ARs) regulated the activation of macrophages in postoperative ileus (POI). The improvement of EA in gastrointestinal motility was mimicked by sympathectomy and α2-adrenoceptors antagonist.
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