A Novel Optical Coherence Tomography–based Keratoconus Diagnostic Index Incorporating Stromal and Epithelial Features

Individual OCT-based machine-derived parameters lack sufficient power to discriminate FFKC and EKC from normal corneas, but this can be improved by combining OCT-based information from stroma and epithelium as in this new index. The discrimination accuracy of the WISE index was comparable to existing Scheimpflug-based indices.