促炎细胞因子
愤怒(情绪)
糖基化
疾病
炎症
医学
线粒体ROS
糖尿病
活性氧
病态的
免疫学
生物
氧化应激
病理
内分泌学
细胞生物学
神经科学
作者
Micheal Ward,Amelia K. Fotheringham,Mark E. Cooper,Josephine M. Forbes
标识
DOI:10.1016/j.coph.2013.06.009
摘要
Cardiovascular disease (CVD) is a leading cause of mortality in the Western World. The development and onset of disease can be attributed to many risk factors including genetic susceptibility, diabetes, obesity and atherosclerosis. Numerous studies highlight the production of advanced glycation endproducts (AGEs) and interaction with their receptor (RAGE) as playing a key pathogenic role. The AGEs–RAGE axis is thought to contribute to a proinflammatory environment inducing cellular dysfunction which cascades towards pathology. Mitochondrial dysfunction concurrently plays a role in these proinflammatory responses presenting excess reactive oxygen species (ROS) production under pathological conditions. This ROS release can exacerbate the production of AGEs fuelling the fire somewhat. However, the AGEs–RAGE axis may influence mitochondrial function independently of inflammation. Therefore instigation of the AGEs–RAGE axis may facilitate spiralling towards pathology on many fronts including CVD development.
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