Biofunctionalization of Fluorescent Rare‐Earth‐Doped Lanthanum Phosphate Colloidal Nanoparticles

Approximately eight avidin molecules are conjugated to each Ce/Tb-doped lanthanum phosphate nanoparticle (NP) through the formation of amide bonds (see scheme). This biofunctionalization process comprises modification of the LaPO4 NPs with 6-aminohexanoic acid (AHA) to confer colloidal stability, activation of the AHA carboxy groups by 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide, and avidin conjugation. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z460856_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.