苯丙氨酸羟化酶
四氢生物蝶呤
苯丙氨酸
变构调节
酪氨酸羟化酶
酪氨酸
酶
化学
生物化学
磷酸化
辅因子
氨基酸
标识
DOI:10.1016/j.abb.2011.09.012
摘要
The liver enzyme phenylalanine hydroxylase is responsible for conversion of excess phenylalanine in the diet to tyrosine. Phenylalanine hydroxylase is activated by phenylalanine; this activation is inhibited by the physiological reducing substrate tetrahydrobiopterin. Phosphorylation of Ser16 lowers the concentration of phenylalanine for activation. This review discusses the present understanding of the molecular details of the allosteric regulation of the enzyme.
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