肌球蛋白
Jurkat细胞
细胞迁移
白血病
肌球蛋白轻链激酶
细胞生物学
细胞培养
生物
化学
细胞
分子生物学
免疫学
生物化学
T细胞
免疫系统
遗传学
作者
Jbireal M. Ali Jbireal,Carina Strell,Bernd Niggemann,Kurt S. Zänker,Frank Entschladen
标识
DOI:10.1016/j.leukres.2010.04.018
摘要
Several myosin isotypes are discussed to be involved in the migration of various cells ranging from tumor cells to leukocytes. We investigated the involvement of myosins II and VI in the lymphoid leukemia cells lines Jurkat, NB4, Dohh-2, and Molt-4 by a three-dimensional, collagen-based migration assay. Down-regulation of myosin VI by siRNA significantly reduced the migratory activity of all cells, whereas the pharmacological inhibition of non-muscle myosin II using blebbistatin had only marginal influence. Therefore, in contrast to differentiated leukocytes and cells from solid tumors, myosin VI plays a crucial role in the migration of leukemic cells.
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