Mechanism-Based Inactivation (MBI) of Cytochrome P450 Enzymes: Structure–Activity Relationships and Discovery Strategies To Mitigate Drug–Drug Interaction Risks

ADVERTISEMENT RETURN TO ISSUEPREVPerspectiveNEXTMechanism-Based Inactivation (MBI) of Cytochrome P450 Enzymes: Structure–Activity Relationships and Discovery Strategies To Mitigate Drug–Drug Interaction RisksSuvi T. M. Orr†, Sharon L. Ripp‡, T. Eric Ballard†, Jaclyn L. Henderson†, Dennis O. Scott§, R. Scott Obach‡, Hao Sun‡, and Amit S. Kalgutkar*§View Author Information‡ †Worldwide Medicinal Chemistry and ‡Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States§ Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, 620 Memorial Drive, Cambridge, Massachusetts 02139, United States*Phone: (617) 551-3336. E-mail: [email protected]Cite this: J. Med. Chem. 2012, 55, 11, 4896–4933Publication Date (Web):March 12, 2012Publication History Received15 January 2012Published online27 March 2012Published inissue 14 June 2012https://pubs.acs.org/doi/10.1021/jm300065hhttps://doi.org/10.1021/jm300065hreview-articleACS PublicationsCopyright © 2012 American Chemical SocietyRequest reuse permissionsArticle Views13560Altmetric-Citations168LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Bioinorganic chemistry,Genetics,Inhibitors,Metabolism,Peptides and proteins Get e-Alerts