T细胞受体
嵌合抗原受体
免疫突触
受体
CD28
免疫学
T细胞
生物
免疫系统
神经科学
癌症研究
细胞生物学
遗传学
作者
Shivani Srivastava,Stanley R. Riddell
标识
DOI:10.1016/j.it.2015.06.004
摘要
Despite being empirically designed based on a simple understanding of TCR signaling, T cells engineered with chimeric antigen receptors (CARs) have been remarkably successful in treating patients with advanced refractory B cell malignancies. However, many challenges remain in improving the safety and efficacy of this therapy and extending it toward the treatment of epithelial cancers. Other aspects of TCR signaling beyond those directly provided by CD3ζ and CD28 phosphorylation strongly influence a T cell's ability to differentiate and acquire full effector functions. Here, we discuss how the principles of TCR recognition, including spatial constraints, Kon/Koff rates, and synapse formation, along with in-depth analysis of CAR signaling might be applied to develop safer and more effective synthetic tumor targeting receptors.
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