群体感应
铜绿假单胞菌
表型
微生物学
绿脓素
假单胞菌
生物膜
假单胞菌科
群体猝灭
生物
化学
细菌
突变体
假单胞菌
高丝氨酸
群集运动
作者
Anabela Borges,Pedro Sousa,Alexandra Gaspar,Santiago Vilar,Fernanda Borges,Manuel Simões
出处
期刊:Biofouling
[Informa]
日期:2017-01-31
卷期号:33 (2): 156-168
被引量:20
标识
DOI:10.1080/08927014.2017.1280732
摘要
Disruption of cell-cell communication or quorum sensing (QS) is considered a stimulating approach for reducing bacterial pathogenicity and resistance. Although several QS inhibitors (QSIs) have been discovered so far their clinical use remains distant. This problem can be circumvented by searching for QSI among drugs already approved for the treatment of different diseases. In this context, antibiotics have earned special attention. Whereas at high concentrations antibiotics exert a killing effect, at lower concentrations they may act as signaling molecules and as such can modulate gene expression. In this study, the antibiotic furvina was shown to be able to cause inhibition of the 3-oxo-C12-HSL-dependent QS system of Pseudomonas aeruginosa. Furvina interacts with the LasI/LasR system. The data were validated by modeling studies. Furvina can also reduce biofilm formation and decrease the production of QS-controlled virulence factors.
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