三磷酸腺苷
摩尔浓度
化学
增溶
两亲性
分子
水溶液
合作性
摩尔比
腺苷
生物物理学
生物化学
生物
有机化学
共聚物
催化作用
聚合物
作者
Avinash Patel,Liliana Malinovska,Shambaditya Saha,Jie Wang,Simon Alberti,Yamuna Krishnan,Anthony Hyman
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2017-05-19
卷期号:356 (6339): 753-756
被引量:655
标识
DOI:10.1126/science.aaf6846
摘要
Hydrotropes are small molecules that solubilize hydrophobic molecules in aqueous solutions. Typically, hydrotropes are amphiphilic molecules and differ from classical surfactants in that they have low cooperativity of aggregation and work at molar concentrations. Here, we show that adenosine triphosphate (ATP) has properties of a biological hydrotrope. It can both prevent the formation of and dissolve previously formed protein aggregates. This chemical property is manifested at physiological concentrations between 5 and 10 millimolar. Therefore, in addition to being an energy source for biological reactions, for which micromolar concentrations are sufficient, we propose that millimolar concentrations of ATP may act to keep proteins soluble. This may in part explain why ATP is maintained in such high concentrations in cells.
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