细胞滋养层
医学
绒毛膜癌
免疫组织化学
滋养层
合胞滋养细胞
组织微阵列
病态的
病理
胎盘部位滋养细胞肿瘤
肿瘤科
胎盘
怀孕
胎儿
生物
遗传学
作者
Pierre‐Adrien Bolze,Sophie Patrier,Jérôme Massardier,Touria Hajri,Fatima Abbas,Anne-Marie Schott,Fabienne Allias,Mojgan Devouassoux‐Shisheboran,Gilles Freyer,François Golfier,Benoît You
出处
期刊:International Journal of Gynecological Cancer
[BMJ]
日期:2017-03-01
卷期号:27 (3): 554-561
被引量:66
标识
DOI:10.1097/igc.0000000000000892
摘要
Recently reported expression of programmed cell death 1 ligand 1 (PD-L1) in gestational trophoblastic diseases (GTDs) suggests that the immune tolerance of pregnancy might be hijacked during neoplastic process. We assessed PD-L1 protein expression in premalignant and malignant GTD lesions and analyzed associations with disease severity and chemotherapy outcomes.We included 83 GTD whole-tissue sections from 76 patients in different treatment settings. PD-L1 protein expression was assessed with immunohistochemistry in each trophoblast subtype with the Allred total score (ATS), which combines intensity and proportion expression on a 0- to 8-point scale. Peritumoral immune infiltrate was scored on hematoxylin-eosin-safran-stained slides.PD-L1 expression was ubiquitous and strong in all GTD trophoblast subtypes. For invasive moles, ATS scores were maximal at 8 in 100%, 100%, and 75% of syncytiotrophoblast, villous cytotrophoblast, and extravillous cytotrophoblast specimens, respectively. For choriocarcinomas, ATS was 8 in 80% of specimens. Immune infiltrates were moderate to severe in 61%, 100%, and 100% of peritumoral zones of choriocarcinoma, epithelioid trophoblastic tumor, and invasive moles, respectively. Because of the homogeneous pathological findings, no significant differences in PD-L1 expression profiles or peritumoral immune infiltrates were found regarding FIGO (International Federation of Gynecology Obstetrics) prognostic score, fatal outcome, or chemosensitivity.We confirm that PD-L1 is constitutively expressed in all GTD premalignant and malignant trophoblast subtypes, independently from FIGO score, chemoresistance, or fatal outcomes, thereby suggesting a crucial role for PD-L1 in the development and tolerance of GTD. Assessment of anti-PD-L1 drug in GTD patients has been activated.
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