刺激
甲酚紫
电极
生物医学工程
脉搏(音乐)
材料科学
H&E染色
医学
化学
解剖
病理
光学
物理
染色
内科学
探测器
物理化学
作者
Barry Gordon,Ronald P. Lesser,Naomi E. Rance,John Hart,Robert Webber,Sumio Uematsu,Robert S. Fisher
出处
期刊:Electroencephalography and Clinical Neurophysiology
[Elsevier]
日期:1990-05-01
卷期号:75 (5): 371-377
被引量:202
标识
DOI:10.1016/0013-4694(90)90082-u
摘要
Safe parameters for electrical cortical stimulation in humans are difficult to estimate from the animal experimental literature. We therefore examined the light microscopic histology at a total of 11 sites of direct subdural electrical stimulation, taken as part of anterior temporal lobectomies in 3 patients. Stimulations had been done through 3.175 mm diameter electrodes, with 0.3 msec square wave pulses of alternating polarity at 50 pulses/sec. In 2 patients, one site each had been used as a common reference for stimulation, receiving over 251 stimulation trials, most of 2-5 sec duration, at currents of 12.5-15.0 mA, 1 day prior to resection. The maximum charge per phase was 4.0-4.4 microC; the maximum charge density was 52-57 microC per geometric cm2 per pulse at the electrode surfaces. Comparison of hematoxylin and eosin, periodic acid-Schiff, and cresyl violet-stained material from the electrode sites with that from other regions did not show any histologic abnormalities attributable to the electrical stimulation. The relatively brief and intermittent periods utilized for human stimulation testing do not appear to cause structural damage at the light microscopic level at charge densities that exceed the threshold for damage established in animal studies with more continuous, chronic stimulation schedules.
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