精胺
抗氧化剂
硫代巴比妥酸
化学
超氧化物歧化酶
谷胱甘肽还原酶
体内
缺血
谷胱甘肽
药理学
生物化学
酶
内科学
医学
生物
脂质过氧化
谷胱甘肽过氧化物酶
生物技术
作者
R Farbiszewski,Krzysztof Bielawski,Anna Bielawska,Wojciech Sobaniec
出处
期刊:Acta Neurobiologiae Experimentalis
[Exeley, Inc.]
日期:1995-12-31
卷期号:55 (4): 253-258
被引量:18
标识
DOI:10.55782/ane-1995-1084
摘要
The antioxidant enzymatic system in brain hypoperfusion/reperfusion model in rats after spermine administration was evaluated. Incomplete cerebral ischemia/reperfusion induced by temporal occlusion of common carotid arteries caused a decrease in the activities of superoxide dismutase and glutathione reductase as well as total and free sulfhydryl groups, while thiobarbituric acid-reactive substances became elevated. Administration of spermine after the reperfusion led to restoring all above parameters to normal values. Protective effect of spermine in transiently hypoperfused and subsequently reperfused rat brain is briefly discussed.
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