炎症
癌症
调解人
免疫学
免疫
NF-κB
癌症研究
IκB激酶
NFKB1型
免疫系统
医学
激酶
生物
转录因子
细胞生物学
遗传学
基因
作者
Michael Karin,Florian R. Greten
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2005-09-20
卷期号:5 (10): 749-759
被引量:2750
摘要
There has been much effort recently to probe the long-recognized relationship between the pathological processes of infection, inflammation and cancer. For example, epidemiological studies have shown that approximately 15% of human deaths from cancer are associated with chronic viral or bacterial infections. This Review focuses on the molecular mechanisms that connect infection, inflammation and cancer, and it puts forward the hypothesis that activation of nuclear factor-kappaB (NF-kappaB) by the classical, IKK-beta (inhibitor-of-NF-kappaB kinase-beta)-dependent pathway is a crucial mediator of inflammation-induced tumour growth and progression, as well as an important modulator of tumour surveillance and rejection.
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