Mild and Efficient Synthesis of m ‐Aminobenzamides via Palladium‐Catalyzed Aminocarbonylation of m ‐Iodoanilines With Amine Hydrochlorides

ABSTRACT An efficient palladium‐catalyzed aminocarbonylation protocol for the synthesis of m ‐aminobenzamides has been developed using m ‐iodoanilines and amine hydrochlorides under 1 atm of carbon monoxide (CO). This transformation proceeds under mild conditions, featuring excellent functional group tolerance, broad substrate scope, and high isolated yields. Remarkably, the free amino group of m ‐iodoaniline remains unprotected throughout the reaction. This protocol provides a practical and complementary synthetic route to structurally diverse m ‐aminobenzamides.