骨质疏松症
骨愈合
骨形成
骨重建
药物输送
体内
纳米技术
骨折
骨生长
生物相容性
作者
Adriana Gilarska,Alicja Hinz,Monika Bzowska,Grzegorz Dyduch,Kamil Kamiński,Maria Nowakowska,Joanna Lewandowska-Łańcucka
标识
DOI:10.1021/acsami.1c17472
摘要
Novel multifunctional biomimetic injectable hybrid systems were synthesized. The physicochemical as well as biological in vitro and in vivo tests demonstrated that they are promising candidates for bone tissue regeneration. The hybrids are composed of a biopolymeric collagen/chitosan/hyaluronic acid matrix and amine group-functionalized silica particles decorated with apatite to which the alendronate molecules were coordinated. The components of these systems were integrated and stabilized by cross-linking with genipin, a compound of natural origin. They can be precisely injected into the diseased tissue in the form of a viscous sol or a partially cross-linked hydrogel, where they can serve as scaffolds for locally controlled bone tissue regeneration/remodeling by supporting the osteoblast formation/proliferation and maintaining the optimal osteoclast level. These materials lack systemic toxicity. They can be particularly useful for the repair of small osteoporotic bone defects.
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