生物
RNA结合蛋白
RNA剪接
剪接体
选择性拼接
细胞生物学
拼接因子
外显子
信使核糖核酸
遗传学
神经科学
核糖核酸
基因
作者
Katarzyna Bartkowska,Beata Tepper,K Turlejski,R Djavadian
出处
期刊:Reviews in The Neurosciences
[De Gruyter]
日期:2018-05-23
卷期号:29 (8): 817-824
被引量:13
标识
DOI:10.1515/revneuro-2017-0113
摘要
Abstract The exon junction complex (EJC) consists of four core proteins: Magoh, RNA-binding motif 8A (Rbm8a, also known as Y14), eukaryotic initiation factor 4A3 (eIF4A3, also known as DDX48), and metastatic lymph node 51 (MLN51, also known as Casc3 or Barentsz), which are involved in the regulation of many processes occurring between gene transcription and protein translation. Its main role is to assemble into spliceosomes at the exon-exon junction of mRNA during splicing. It is, therefore, a range of functions concerning post-splicing events such as mRNA translocation, translation, and nonsense-mediated mRNA decay (NMD). Apart from this, proteins of the EJC control the splicing of specific pre-mRNAs, for example, splicing of the mapk transcript. Recent studies support essential functions of EJC proteins in oocytes and, after fertilization, in all stages of zygote development, as well as the growth of the embryo, including the development of the nervous system. During the development of the central nervous system (CNS), the EJC controls mitosis, regulating both symmetric and asymmetric cell divisions. Reduced levels of EJC components cause microcephaly. In the adult brain, Y14 and eIF4A3 appear to be involved in synaptic plasticity and in learning and memory. In this review, we focus on the involvement of EJC components in brain development and its functioning under normal conditions.
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