神经炎症
化学
一氧化氮
氧化应激
查尔酮
药理学
生物化学
传统医学
生物
立体化学
炎症
医学
免疫学
有机化学
作者
Ning Li,Dali Meng,Yuexiao Pan,Qingling Cui,Guoxun Li,Hui Ni,Yu Sun,Degang Qing,Xiaobin Jia,Yingni Pan,Yue Hou
标识
DOI:10.1016/j.jff.2015.06.027
摘要
Oxidative stress and neuroinflammation are critical in the pathogenesis of neurodegenerative diseases. Extract of Coreopsis tinctoria Nutt. has been shown to ameliorate neurodegenerative diseases, potentially via inducing quinone oxidoreductase 1 (NQO1) and anti-neuroinflammation. The present study aimed to characterize the chemical profile and bioactive composition of the extract to identify the effective components responsible for the effects. Chromatography and spectra analysis yielded 26 constituents, including a new chalcone (compound 8). Bioassays showed that compounds 6, 9, 15, 17, 19, 21 and 22 significantly inhibited production of nitric oxide (NO) in N9 cells induced by lipopolysaccharides (LPS). Meanwhile compounds 1, 3, 6, 11, 19 and 20 exhibited significant NQO1 inducing activities in Hepa 1c1c7 cells. These results suggest that extract of C. tinctoria Nutt. contains bioactive components attenuating the progress of neurodegenerative diseases, thus, a valuable functional food for the prevention of neurodegenerative diseases.
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