回顾性分析
化学
聚酮
模块化设计
组合化学
全合成
纳米技术
立体化学
计算机科学
有机化学
生物合成
程序设计语言
酶
材料科学
作者
Jian Li,Fuzhuo Li,Emma King‐Smith,Hans Renata
出处
期刊:Nature Chemistry
[Springer Nature]
日期:2020-01-20
卷期号:12 (2): 173-179
被引量:69
标识
DOI:10.1038/s41557-019-0407-6
摘要
Meroterpenoids are natural products of hybrid biosynthetic origins—derived from both terpenoid and polyketide pathways—with a wealth of biological activities. Given their therapeutic potential, a general strategy to access these natural products in a concise and divergent fashion is highly desirable. Here, we report a modular synthesis of a suite of oxidized meroterpenoids using a hybrid synthetic strategy that is designed to harness the power of both biocatalytic and radical-based retrosynthetic logic. This strategy enables direct introduction of key hydroxyl groups and rapid construction of key bonds and stereocentres, facilitating the development of a concise route (7–12 steps from commercial materials) to eight oxidized meroterpenoids from two common molecular scaffolds. This work lays the foundation for rapid access to a wide range of oxidized meroterpenoids through the use of similar hybrid strategy that combines two synthetic approaches. Meroterpenoids are mixed terpenoid–polyketide natural products that exhibit a range of biological activities. A hybrid synthetic strategy that combines biocatalytic and radical-based methods has now been developed and it enables eight different oxidized meroterpenoids to be made in just 7–12 steps from commercially available materials.
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