抗逆转录病毒疗法
人类免疫缺陷病毒(HIV)
医学
家庭医学
替代医学
老年学
病毒载量
病理
作者
Laura Clark,Chitra Karki,Josh Noone,Jenny Scherzer,Martina Bode,Paolo Rizzini,Fabio Maria Vecchio,Laëtitia Roustand,Gaëlle Nachbaur,Laurent Finkielsztejn,Vasiliki Chounta,Nicolas Van de Velde
标识
DOI:10.18332/popmed/126632
摘要
INTRODUCTION Current antiretroviral therapies (ARTs) require daily oral dosing, which is a challenge for some people living with HIV (PLHIV).Measures of treatment needs that are associated with daily oral ARTs have been identified in studies/ interviews with healthcare professionals (HCPs) and PLHIV, and are grouped in four main categories: 1) medical conditions interfering with daily oral administration, 2) suboptimal adherence, 3) confidentiality concerns, and 4) emotional wellbeing related to daily tablet requirements.We quantified these categories to assess the potential benefits of alternatives to daily oral ARTs such as long-acting injectable regimens.METHODS Two separate online studies were completed by HCPs (n=120) and PLHIV (n=698) in France, Germany, Italy and the UK, in 2019.HCPs reported the number and percentage of their patients with challenges; unit of analysis among PLHIV was the respondents (%).Descriptive analyses were performed with R 3.6.1.RESULTS HIV physicians reported managing a mean of 299 (SD=177) patients, of whom 85.7% were on ART.Among PLHIV, 98.6% (688/698) were currently on ART, with mean age of 40.9 (SD=12.0)years, and 66.4% men.HCPs estimated that 10-15% of their patients were affected by each medical condition identified as interfering with daily oral administration.HCPs further estimated that 33.6% of their patients were suboptimally adherent.'Non-adherence for any non-medical reason' was reported by HCPs as the primary cause of virologic failure.Of surveyed PLHIV on ART, 43.3% (298/688) reported hiding their medication and 29.7% (204/688) indicated they had never shared their HIV status with others.Furthermore, some PLHIV reported that having to remember to dose at the right time every day was stressful (27.3%; 188/688) and many saw their tablets as a daily reminder of HIV (45.1%; 310/688).CONCLUSIONS A significant proportion of PLHIV struggle with daily oral ART because of medical and/or HIV-specific issues.
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