Palladium‐Catalyzed Selective Three‐Component Tandem Reaction to Bicyclic 1,2,3‐Triazole Derivatives

Abstract A Pd‐catalyzed highly selective tandem reaction of allenynes, aryl or alkenyl iodides, and sodium azide for the synthesis of bicyclic 1,2,3‐triazole derivatives with a very broad substrate scope including mono‐substituted, 1,3‐disubstituted, and trisubstituted allenynes as well as different types of organic iodides has been reported. Control experiments showed that the reaction went through a cascade allene difunctionalization/Winstein allylic azide rearrangement/intramolecular azide‐alkyne cycloaddition process. magnified image