生物
分泌物
效应器
水平基因转移
分泌素家族
计算生物学
进化生物学
分子机器
基因
遗传学
细胞生物学
系统发育学
受体
血管活性肠肽
生物化学
神经肽
作者
Rémi Denise,Sophie S. Abby,Eduardo P. C. Rocha
标识
DOI:10.1016/j.tim.2020.01.005
摘要
Protein secretion is important for many biotic and abiotic interactions. The evolution of protein secretion systems of bacteria, and related nanomachines, occurred by the co-option of machineries for motility, conjugation, injection, or adhesion. Some of these secretion systems emerged many times, whereas others are unique. In most cases, their evolution occurred by successive rounds of gene accretion, deletion, and horizontal transfer, resulting in machines that can be very different from the original ones. The frequency with which such co-option processes occurred seems to depend on the complexity of the systems, their differences to the ancestral machines, the availability of genetic material to tinker with, and possibly on the mechanisms of effector recognition. Understanding the evolution of secretion systems illuminates their functional diversification and could drive the discovery of novel systems.
科研通智能强力驱动
Strongly Powered by AbleSci AI