材料科学
临床前影像学
生物物理学
光化学
组合化学
荧光寿命成像显微镜
作者
Chunbin Li,Guoyu Jiang,Xiang Liu,Qingfang Lai,Miaomiao Kang,Dong Wang,Pengfei Zhang,Jianguo Wang,Ben Zhong Tang
出处
期刊:Materials Chemistry Frontiers
[The Royal Society of Chemistry]
日期:2021-02-23
卷期号:5 (4): 1817-1823
被引量:4
摘要
Nitroxyl (HNO), as a reactive nitrogen species (RNS), has a pivotal role in many physiological and pathological processes, but the generation mechanism of endogeneous HNO has not been elucidated, because of the lack of highly sensitive and selective probes to achieve real-time visualization and monitoring of HNO in biosystems. Ratiometric fluorescence probes have emerged as powerful platforms for bioimaging applications due to their high sensitivity and anti-interference ability. In this work, we developed firstly a ratiometric fluorescent probe (TCFPB-HNO) with typical aggregation-induced emission (AIE) characteristics for the detection and visualization of HNO with excellent photostability, high specificity and sensitivity. Importantly, TCFPB-HNO was facilely fabricated in high yields via a two-step process, as a serviceable AIE toolbox, which could be employed for real-time monitoring of the HNO level in live samples.
科研通智能强力驱动
Strongly Powered by AbleSci AI