光动力疗法
光敏剂
荧光
紧身衣
共域化
癌细胞
聚集诱导发射
溶酶体
生物物理学
纳米技术
癌症治疗
化学
光学成像
荧光寿命成像显微镜
发光
活性氧
癌症治疗
烧蚀
辐照
结合
光化学
光学透明度
小分子
作者
Yanpeng Dai,Fangru He,Hefang Ji,Xinxin Zhao,Saima Misal,Zhengjian Qi
出处
期刊:ACS Sensors
[American Chemical Society]
日期:2019-12-19
卷期号:5 (1): 225-233
被引量:65
标识
DOI:10.1021/acssensors.9b02090
摘要
Design and synthesis of water-soluble near-infrared (NIR) emissive fluorescent molecules with aggregation-induced emission (AIE) characteristics, perfect signal-to-noise ratio for imaging of organelle, and photodynamic therapy (PDT) functions has received enormous attention. However, the dual-functional NIR AIEgens of high-fidelity tracking lysosome and ablation cancer cells was rarely reported. Herein, a series of AIE luminogens (AIEgens) with a typical AIE effect, good biocompatibility, superior photostability, high brightness, and excellent reactive oxygen species (ROS) generation ability were developed, which had different electronic push-pull strength and conjugate system size in the molecular structure. These AIEgens could specifically "light up" and dynamically long-term track the lysosomes in living cells and zebrafish with ultrahigh colocalization imaging Pearson's correlation coefficients (Rr: 0.9687) and overlap coefficient (R: 0.9967). Additionally, the MPAT of NIR luminescence as a photosensitizer was used for photodynamic ablation of cancer cells, owing to prompt generation of the ROS under green light irradiation (495-530 nm, 10 mW cm-2). Hence, this research not only expands the application range of NIR AIEgens but also provides useful insights into design of split-new method for the treatment of cancer.
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