CD47型
药物输送
肽
吞噬作用
先天免疫系统
细胞生物学
免疫系统
化学
纳米颗粒
生物物理学
纳米技术
生物化学
生物
免疫学
受体
材料科学
有机化学
作者
Pia L. Rodriguez,Takamasa Harada,David A. Christian,Diego A. Pantano,Richard K. Tsai,Dennis E. Discher
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2013-02-22
卷期号:339 (6122): 971-975
被引量:801
标识
DOI:10.1126/science.1229568
摘要
Stealth Delivery Delivery of therapeutics and imaging agents is hampered by the ability of the innate immune system to recognize and clear foreign particles. "Self" cells are protected from phagocytic clearance by the membrane protein CD47 that interacts with signal regulatory protein-α (SIRPα) on macrophages. Taking advantage of this protective strategy, Rodriguez et al. (p. 971 ) labeled nanoparticles with computationally designed minimal human-CD47–based peptide (hCD47). When injected into a strain of mice in which macrophages expressed a SIRPα that cross-reacts with hCD47, the peptide prevented clearance of nanoparticles and enhanced drug delivery to tumors.
科研通智能强力驱动
Strongly Powered by AbleSci AI