Controlled solid phase peptide bond formation using N-carboxyanhydrides and PEG resins in water.

The increasing need for large quantities of biologically active peptides for the market strongly raised the problem of the environmental sustainability of their synthesis. In this respect, we describe herein a solid phase procedure in water, using PEG peptide amide resins and NCAs under controlled conditions. This procedure afforded with reasonable yield and purity a short peptide amide, without the need of coupling reagents or protecting groups.