维拉帕米
地尔硫卓
钙通道
硝苯地平
白色念珠菌
钙
金黄色葡萄球菌
单核细胞
微生物学
药理学
白色体
医学
吞噬作用
粒细胞
体外
生物活性
大肠杆菌
免疫学
化学
生物
生物化学
内科学
细菌
遗传学
基因
作者
Rachel Lévy,R Dana,Benjamin D. Gold,Muzaffer Alkan,Francisc Schlaeffer
出处
期刊:PubMed
日期:1991-06-01
卷期号:27 (6): 301-6
被引量:6
摘要
The effect of calcium channel blocking agents on the killing activity of human peritoneal polymorphonuclears (PMN) and monocytes was studied. The organisms used were Escherichia coli, Staphylococcus aureus and Candida albicans. The pharmacological concentration of verapamil (5 microM), nifedipine (10 microM) and diltiazem (10 microM) caused a similar inhibition of killing activity in both PMN and monocytes. The calcium channel blockers significantly reduced the in vitro killing of E. coli, S. aureus and C. albicans by PMN to about 47%, 30% and 20% respectively, compared with 81 +/- 6%, 65 +/- 5% and 40 +/- 4% in the controls. The killing of these organisms by monocytes was 60 +/- 6%, 42 +/- 7% and 35 +/- 5% respectively, as compared with 30%, 20% and 17% in the presence of these drugs. The bactericidal activity of the phagocytic cells from patients under treatment with calcium channel blockers was not affected and was found to be within the normal range, indicating that calcium channel blockers do not cause an irreversible impairment in PMN and monocyte killing activity. However, their potential inhibition of phagocytic cell activity should be taken into consideration during treatment.
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