PURPOSE: To study the application of CAD/CAM in individual reconstruction of mandible defects after mandibular tumor resection. METHODS: Four patients with facial defect of unilateral mandibular ameloblastoma were scanned with CT and reconstructed 3-dimentional mandibular images before operation.Simulated models which were similar to their own mandibles were made,then prepared for titanium palate according to the models.In operation,the involved mandible was resected, a segment of the ilium was harvested to implant in the lingual side of the reconstructive titanium palate which had been fixed to the normal position. RESULTS: The measurement of 3D-CT reconstructive image and that of the original model were nearly equal.The Ti-palate reconstruction matched with the mandible.The mandible continuity and functions, and facial contour were satisfactorily rehabilated. Normal height or thickness was shown by X ray. CONCLUSION: The CAD/CAM technique can provide individual models preoperation,improve operation accuracy,save time and lower complications.