Effect of Acarbose and Metformin on Patients with Impaired Glucose Tolerance

Objective To observe the effect of acarbose and metformin on patients with impaired glucose tolerance(IGT).Methods Tofal 82 patients with IGT were randomly divided into two groups(acarbose group and metformin group).Acarbose group took acarbose 50~100mg,three times per day.Metformin group took metformin 250~500mg,three times per day.The study lasted for 12 months.Deteminating FPG、2hPG、TC、TG and HDL before and after the study.Results Both FPG and 2hPG significantly decreased in two groups(P0.05 and P0.01).But 2hPG significantly decreased in acarbose group compaired with that of metformin group(P0.01).TC、TG significantly decreased and HDL significantly increased in two groups,but there were no significant difference in two group.Metformin group can significantly decreased BMI compaired with acarbose group(P0.05).Conclusion Acarbose and metformin can be used to treat IGT patients.