间充质干细胞
干细胞
老化
科克伦图书馆
脂肪组织
脂肪生成
医学
骨髓
生物信息学
生物
细胞生物学
免疫学
病理
荟萃分析
内科学
作者
Hiba Khan,Pouya Mafi,Reza Mafi,Wasim Khan
出处
期刊:Current stem cell research & therapy
[Bentham Science]
日期:2018-05-28
卷期号:13 (5): 378-383
被引量:20
标识
DOI:10.2174/1574888x11666160429122527
摘要
Background: Mesenchymal stem cells (MSC) are unique in their ability to self-renew and differentiate into one of many lineage possibilities. It is therefore integral to preserve these qualities to prevent the far reaching effects of a defective stem cell. Human mesenchymal stem cells (hMSC) are precursors for and can differentiate into osteoblasts, adipocytes and chondrocytes. They were originally found in the bone marrow, but have also been located in the umbilical cord, adipose tissue and muscle. Few studies have been conducted into the in vivo effects of age on these cells. This contribution reviews current knowledge surrounding the effects of age on the characteriation and differentiation of human mesenchymal stem cells. Method: 471 articles were found using a combination of Online published articles from January 1983 to January 2016 were searched using the Cochrane Library, PubMed, Medline, Scopus, Web of Science and Science Direct databases. There were no existing systematic reviews on this research topic. Results: Nine studies were identified that met the predefined selection criteria. Three studies were used to assess the effects of ageing on characterisation of hMSC with no conclusive results. The cumulative results of these studies show that the effect of ageing on characterisation of hMSC remains inconclusive. Seven studies were used to assess the differentiation potentials of hMSC showing that age either decreased or altered lineage preference in hMSC differentiation. Conclusion: There is indication that ageing affects hMSC characterisation and differentiation, however it is not conclusive. There are not enough high quality controlled clinical trials to make reliable conclusions. Keywords: Age, characterisation, differentiation, human mesenchymal stem cells, proliferation, systematic review.
科研通智能强力驱动
Strongly Powered by AbleSci AI