The Empirical Control Test of Using Panaxsaponin Rg_1 and Rb_1 on Hepatic Fibrosis

Objective: To investigate the effect of Panaxsaponin and Rb1 on hepatic fibrosis,which are two of the main ingredients of Panax Notoginsenosides.Methods:Make the rats models of hepatic fibrosis by using 50%CCl4,at the same time,give the Panaxsaponin Rb1 on different doses and Panax Notoginsenosides by hypodermical injection.At the end of the treatment,test the levels of precollagen Ⅲ(pCⅢ)、hyaluronic acid(HA)and laminin(LN)in the blood serum,and investigate the pathological chaneg of hepatic tissue.Results Panax Notoginsenosides can improve hepatic function and degrade the leels of pCⅢ、HA、LN on the rats models,and have the same delectable effect on the pathological change.While Panaxsaponin Rb1 can not improve hepatic fibrosis,moreover it can damage the hepatic function.There are relationship between the degrees of pathological change and the levels of pCⅢ、HA.Conclusion:The levels of pCⅢ、HA in serum are reliable to evaluate hepatic fibrosis.Panaxsapoinin Rb1 is not effective on hepatic fibrosis.Panaxsaponin Rb1 is not one of the effective ingredients of Panax Notoginsenosides which can be used in hepatic fibrosis.