平衡
癌变
生物
钙信号传导
癌症
细胞生物学
癌细胞
细胞信号
转移
信号转导
程序性细胞死亡
细胞内
癌症研究
细胞凋亡
遗传学
作者
Saverio Marchi,Paolo Pinton
标识
DOI:10.1016/j.coph.2016.03.002
摘要
Typical hallmarks of cancer include programmed cell death evasion, uncontrolled cell growth, invasion, and metastasis. Changes in intracellular Ca(2+) levels can modulate signaling pathways that control a broad range of cellular events, including those important to tumorigenesis and cancer progression. Here we discuss how known molecular mediators of cellular Ca(2+) homeostasis impact tumor dynamics and how deregulation of major oncogenes and tumor suppressors is tightly associated with Ca(2+) signaling.
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