The study of static and dynamic stability of the crude oil added with nanometer and GY2 freeze-point depressant was carried out,the new nanometer depressant was more optimal than that of available GY2 freeze-point depressant in freeze-point reduction,viscosity reduction and time stability as it was used in pipelines;The new nanometer freeze-point depressant was used for field test,and it was compared with the GY2 depressant,and the nanometer freeze-point depressant was obtained for freeze-point and viscosity reduction in waxy crude oil with good effect,after two heat treatments oil physical properties was stable,after the complex thermal and shear history,each index of the nano freeze-point depressant is better than that of GY2,and it has a temperature of 5℃ for energy saving space;it obtains advantages of different dosage increase and long time stability of crude oil is obtained.