Objective To observe the clinical therapeutic effect of traditional Chinese herbal medicine adjuvant therapy by oral combined with retention enema on severe acute pancreatitis.Methods A total of 80 patients were randomly divided into the test group and the control group.The control group was treated with conventional western medicine.The test group were treated with traditional Chinese herbal medicine by oral combined with retention enema on the basis of conventional western medicine.Two groups were observed symptoms,signs,white blood cell count,serum amylase,organ function and mortality.The total effective rates were compared.Results The total effective rate of test group was higher than the control group.The difference was statistically significant(P 0.05).Conclusion The therapeutic effect can be improved in the patients with severe acute pancreatitis who used traditional Chinese herbal medicine adjuvant therapy by oral combined with retention enema.