化学
联苯
衍生工具(金融)
位阻效应
铃木反应
无水的
偶联反应
组合化学
液晶
联轴节(管道)
有机化学
催化作用
钯
金融经济学
经济
机械工程
物理
光学
工程类
作者
Andrew N. Cammidge,Karen V. L. Crépy
摘要
A heavily functionalized atropisomeric biphenyl derivative (4), which is designed to possess a large lateral dipole moment, has been synthesized with use of a Suzuki coupling as the key step and resolved by chiral HPLC. The final coupling reaction is complicated by rapid hydrolytic deboronation of the sterically hindered, electron poor boronate 22. Rigorously anhydrous conditions are therefore necessary to achieve the coupling.
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