Theta frequency deep brain stimulation in the subthalamic nucleus improves working memory in Parkinson’s disease

丘脑底核 脑深部刺激 心理学 神经科学 帕金森病 工作记忆 认知 基底神经节 医学 物理医学与康复 疾病 内科学 中枢神经系统
作者
Narges Salehi,Simone Nahrgang,Wiebke Petershagen,Till A. Dembek,David J. Pedrosa,Lars Timmermann,Immo Weber,Carina R. Oehrn
出处
期刊:Brain [Oxford University Press]
卷期号:147 (4): 1190-1196 被引量:18
标识
DOI:10.1093/brain/awad433
摘要

Abstract Most research in Parkinson’s disease focuses on improving motor symptoms. Yet, up to 80% of patients present with non-motor symptoms that often have a large impact on patients’ quality of life. Impairment in working memory, a fundamental cognitive process, is common in Parkinson's disease. While deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor symptoms in Parkinson’s disease, its impact on cognitive functions is less well studied. Here, we examine the effect of DBS in the theta, beta, low and high gamma frequency on working memory in 20 Parkinson's disease patients with bilateral STN-DBS. A linear mixed effects model demonstrates that STN-DBS in the theta frequency improves working memory performance. This effect is frequency-specific and was absent for beta and gamma frequency stimulation. Further, this effect is specific to cognitive performance, as theta frequency DBS did not affect motor function. A non-parametric cluster-based permutation analysis of whole-brain normative structural connectivity shows that working memory enhancement by theta frequency stimulation is associated with higher connectivity between the stimulated subthalamic area and the right middle frontal gyrus. Again, this association is frequency- and task-specific. These findings highlight the potential of theta frequency STN-DBS as a targeted intervention to improve working memory in patients with Parkinson's disease.
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