医学
髓母细胞瘤
溶瘤病毒
非典型畸胎样横纹肌瘤
免疫系统
麻疹病毒
免疫疗法
耐受性
癌症研究
免疫学
肿瘤科
内科学
麻疹
不利影响
接种疫苗
作者
Bohyeon Yu,Cassie Kline,Owen Hoare,Jangham Jung,Truman Knowles,Aeesha Ranavaya,Jane E. Minturn,Anuradha Banerjee,Sarah Leary,Erin Crotty,Mohamed S Abdelbaki,Nicholas Whipple,Stewart Goldman,Ashley Margol,Aashim Bhatia,Nour Dababo,Elizabeth George,Ali Nabavizadeh,Miguel Hernandez Pampaloni,Akihito Inagaki
标识
DOI：10.1158/1078-0432.ccr-24-3721
摘要
This is the first trial investigating intratumoral as well as repeated intrathecal delivery of MV-NIS in children with medulloblastoma and ATRT. We show that the therapy is safe and well tolerated, with minimal adverse effects. Immune markers and biological correlates preliminarily indicate antiviral effects in tumors.
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(2025-6-4)
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