MAPK/ERK通路
细胞凋亡
细胞生长
细胞周期
线粒体分裂
生物
细胞周期检查点
线粒体
激酶
癌变
信号转导
细胞生物学
癌症
化学
生物化学
遗传学
作者
Xiaojie Chen,Qixiao Cui,Guoli Wang,Xiaoli Li,Xiaolin Zhou,Haitao Zhao,Mingqian Zhang,Minjing Li,Xiaojuan He,Qi Zheng,Yuliang Wang,Defang Li,Pan Hong
标识
DOI:10.1021/acs.jnatprod.2c00524
摘要
Sanggenon C is a flavonoid extracted from the root bark of white mulberry, which is a traditional Chinese medicine with anti-inflammatory, antioxidative, and antitumor pharmacological effects. In this study, sanggenon C was found to inhibit human gastric cancer (GC) cell proliferation and colony formation, induce GC cell cycle arrest in the G0-G1 phase, and promote GC cell apoptosis. Moreover, sanggenon C was found to decrease the level of mitochondrial membrane potential in GC cells and inhibit mitochondrial fission. Mechanistically, RNA sequencing, bioinformatics analysis, and a series of functional analyses confirmed that sanggenon C inhibited mitochondrial fission to induce apoptosis by blocking the extracellular regulated protein kinases (ERK) signaling pathway, and constitutive activation of ERK significantly abrogated these effects. Finally, sanggenon C was found to suppress the growth of tumor xenografts in nude mice without obvious side effects to the vital organs of animals. This study reveals that sanggenon C could be a novel therapeutic strategy for GC treatment.
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