机制(生物学)
计算机科学
代表(政治)
门控
人工智能
机器学习
计算生物学
神经科学
生物
哲学
认识论
政治
政治学
法学
作者
Weizhong Zhao,Junze Wu,Luo Shu-jie,Yingjun Ma,Tingting He,Xiaohua Hu
出处
期刊:IEEE Journal of Biomedical and Health Informatics
[Institute of Electrical and Electronics Engineers]
日期:2024-01-01
卷期号:: 1-13
标识
DOI:10.1109/jbhi.2024.3390246
摘要
The crisis of antibiotic resistance has become a significant global threat to human health. Understanding properties of antibiotic resistance genes (ARGs) is the first step to mitigate this issue. Although many methods have been proposed for predicting properties of ARGs, most of these methods focus only on predicting antibiotic classes, while ignoring other properties of ARGs, such as resistance mechanisms and transferability. However, acquiring all of these properties of ARGs can help researchers gain a more comprehensive understanding of the essence of antibiotic resistance, which will facilitate the development of antibiotics. In this paper, the task of predicting properties of ARGs is modeled as a multi-task learning problem, and an effective subtask-aware representation learning-based framework is proposed accordingly. More specifically, property-specific expert networks and shared expert networks are utilized respectively to learn subtask-specific features for each subtask and shared features among different subtasks. In addition, a gating-controlled mechanism is employed to dynamically allocate weights to subtask-specific semantics and shared semantics obtained respectively from property-specific expert networks and shared expert networks, thus adjusting distinctive contributions of subtask-specific features and shared features to achieve optimal performance for each subtask simultaneously. Extensive experiments are conducted on publicly available data, and experimental results demonstrate the effectiveness of the proposed framework on the task of ARGs properties prediction. The data and source codes are available in GitHub at https://github.com/David-WZhao/GCM-ARG.
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