氟胞嘧啶
医学
卡斯波芬金
咪康唑
抗药性
氟康唑
伊曲康唑
白色念珠菌
两性霉素B
肉汤微量稀释
内科学
荟萃分析
微生物学
抗真菌
生物
皮肤病科
最小抑制浓度
抗生素
作者
Sarah Quadros Santos Kessler,Pauline A. Lang,Tatiane Silva Dal-Pizzol,Francisco Montagner
标识
DOI:10.1007/s00784-022-04716-2
摘要
To identify the antifungal susceptibility profile of Candida spp. isolated from the human oral cavity was assessed with meta-analyses of observational studies that collected samples from the oral cavity of human subjects.Isolated Candida albicans tested by E-test®; disk diffusion test; microdilution and macrodilution; Sensititre YeastOne; and/or FungiTest. Search strategies were conducted on the MEDLINE, Embase, CINAHL, Dentistry, and Oral Sciences, Central, Scopus, and LILACS databases, and gray literature sources. Articles were initially screened by title and then their abstracts. Articles that met the conditions for inclusion were read in full, followed by data extraction. A descriptive analysis was conducted of each study, and the data were tabulated. A first meta-analysis was conducted to assess the resistance of antifungals regardless of systemic comorbidities. An additional stratified analysis was conducted by systemic comorbidity groups for the outcome "resistance" to the antifungals.When not grouping Candida albicans isolates by systemic conditions, the lowest resistance rates to the antifungals tested were observed for amphotericin B, nystatin, flucytosine, and caspofungin. In contrast, the highest resistance rates were observed for miconazole and econazole. There was a high degree of heterogeneity and low resistance in general in all analyses, except for the "several associated comorbidities" group, which had high resistance rates.Clinical C. albicans isolates had low antifungal resistance.The presence of concomitant systemic comorbidities appears to be an essential factor that should be considered when evaluating resistance to antifungals for oral isolates.
科研通智能强力驱动
Strongly Powered by AbleSci AI