Chiral Nanozymes for Enantioselective Biological Catalysis

As a neat combination of the characteristics of enzymatic activity and nanomaterials, nanozymes have attracted much attention. Although tremendous effort has been devoted to developing nanozymes with high catalytic activity, substrate selectivity is often overlooked in the construction of nanozymes. With their subtly evolving structures, natural enzymes generally possess high selectivity for chiral substrates which play important roles in biosynthesis and biomedical applications. However, the rational construction of nanozymes with high enantioselectivity remains a significant challenge. In this Minireview, we provide an overview of recent advances in strategies for the synthesis of chiral nanozymes and their enantioselective biological catalysis. We further focus on current challenges, potential solutions, and future developing trends of chiral nanozyme-based enantioselective biological catalysis. There is plenty of room to explore. This Minireview will provide new insights into the development of chiral nanozymes and their applications.