An Algorithm for the Diagnosis and Management of Severe Asthma in Children and Adolescents

Severe asthma (SA) in childhood is infrequent (≈2% of all paediatric asthma), yet it drives a disproportionate share of morbidity and cost. A clear algorithm is required to distinguish difficult-to-treat asthma (DTA) from true SA and to guide phenotype-driven diagnosis and therapy.