Improving Soft Tissue Integration of Acrylic Resin by Compositing with Bioactive Glass

With the extensive application of implants in tissue and organ repair, their integration with surrounding tissues is attracting increasing attention. Soft tissue is characterized by high dynamic strain and a complex immune microenvironment, imposing stringent requirements on the mechanical properties, biocompatibility, and surface characteristics of implanted materials. Therefore, compared to the success in implant/hard tissue integration, implant/soft tissue integration remains challenging, and failure to form a stable implant/soft tissue interface is often observed, leading to inflammation, tissue rejection, or even implant failure. To address this issue, we developed acrylic resin/bioactive glass composites. It was found that compositing bioactive glass significantly improved the soft tissue integration of the acrylic resin and effectively reduced its inflammatory response. A demonstration of the obtained composite in subgingival dentin defect restoration showed improved gingival covering and biological seal, highlighting its potential applications in cases where soft tissue integration is essential.